{"id":173,"date":"2020-10-23T15:30:30","date_gmt":"2020-10-23T15:30:30","guid":{"rendered":"https:\/\/www.laboratoriodiprever.com.br\/?page_id=173"},"modified":"2020-12-07T20:15:43","modified_gmt":"2020-12-07T20:15:43","slug":"patologia-molecular-biologia-molecular","status":"publish","type":"page","link":"https:\/\/www.laboratoriodiprever.com.br\/patologia-molecular-biologia-molecular\/","title":{"rendered":"Patologia Molecular\/ Biologia Molecular"},"content":{"rendered":"\t\t
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Patologia Molecular\/ Biologia Molecular<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Os exames de Patologia Molecular\/ Biologia Molecular consistem na avalia\u00e7\u00e3o minuciosa de altera\u00e7\u00f5es g\u00eanicas presentes em diversas cadeias de funcionamento do corpo humano. Dessa forma, podemos pesquisar desde uma altera\u00e7\u00e3o de uma \u00fanica cadeia de base do DNA, at\u00e9 quimerismos complexos de todo o cari\u00f3tipo ou exoma humano.<\/p>

Trata-se de um grupo heterog\u00eaneo de testes que possuem as mais diversas finalidades. Dentro do \u00e2mbito da patologia humana assistencial, essa \u00e1rea \u00e9 respons\u00e1vel por in\u00fameros avan\u00e7os para a melhoria da vida das pessoas.<\/p>

As utiliza\u00e7\u00f5es s\u00e3o diversas, passando por pesquisas de muta\u00e7\u00f5es, que permitem a utiliza\u00e7\u00e3o de drogas espec\u00edficas (Ex.: Muta\u00e7\u00e3o do EGFR em c\u00e2ncer de pulm\u00e3o), a inser\u00e7\u00f5es e dele\u00e7\u00f5es que permitam um diagn\u00f3stico mais preciso (Ex.: Co-dele\u00e7\u00e3o do 1p19q no Oligodendroglioma), assim como transloca\u00e7\u00f5es que indiquem a grupos de neoplasias mais agressivas (Ex.: Transloca\u00e7\u00f5es do gene BCL2, BCL6 e MYC em Linfomas). Al\u00e9m disso, pode-se realizar testes de genotipagem de agentes infeciosos como HPV (sigla em ingl\u00eas para Papilomav\u00edrus Humano) e outras doen\u00e7as sexualmente transmiss\u00edveis.<\/p>

Uma grande dissemina\u00e7\u00e3o recente \u00e9 a utiliza\u00e7\u00e3o de pain\u00e9is moleculares multigenes, os quais permitem realizar m\u00faltiplas pesquisas em pequenas quantidades de material. Geralmente, esses pain\u00e9is s\u00e3o utilizados na classifica\u00e7\u00e3o molecular de alguns tumores, de forma que, de acordo com o grupo molecular, o tratamento ser\u00e1 otimizado, mas tamb\u00e9m para avaliar a possibilidade de s\u00edndromes gen\u00e9ticas que predisp\u00f5em ao surgimento de m\u00faltiplos tumores (Ex.: S\u00edndrome de Lynch).<\/p>

Ap\u00f3s o diagn\u00f3stico Anatomopatol\u00f3gico e\/ou Imuno-Histoqu\u00edmico \u00e9 que, normalmente, surge a indica\u00e7\u00e3o da realiza\u00e7\u00e3o de testes moleculares, os quais ser\u00e3o realizados no pr\u00f3prio material do anatomopatol\u00f3gico. Por serem testes delicados, os exames requerem um prazo maior de libera\u00e7\u00e3o, especialmente nos casos em que se fazem m\u00faltiplos testes.<\/p>

O laborat\u00f3rio DI PREVER disp\u00f5e de um portf\u00f3lio amplo de testes moleculares para auxiliar os m\u00e9dicos nas tomadas de decis\u00f5es. Na tabela abaixo, encontram-se alguns dos principais testes realizados pelo Laborat\u00f3rio DI PREVER. Al\u00e9m disso, dispomos de um canal m\u00e9dico exclusivo com o nosso m\u00e9dico patologista respons\u00e1vel, o qual realizar\u00e1 as an\u00e1lises e poder\u00e1 auxiliar o m\u00e9dico assistente nos questionamentos envolvendo os resultados e as an\u00e1lises moleculares realizadas.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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OBS:<\/strong> Al\u00e9m dos testes moleculares abaixo, o Laborat\u00f3rio DI PREVER disp\u00f5e de uma parceria exclusiva com a Quest Diagnostics<\/em> (EUA, Calif\u00f3rnia) para o oferecimento de testes moleculares que n\u00e3o est\u00e3o dispon\u00edveis no Brasil. Para a utiliza\u00e7\u00e3o dessa ferramenta, o m\u00e9dico assistente dever\u00e1 entrar em contato atrav\u00e9s do nosso canal m\u00e9dico.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Refer\u00eancias<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

NETTO, George J.; SAAD, Rana D.; DYSERT, Peter A. Diagnostic molecular pathology: current techniques and clinical applications, part I. Baylor University Medical Center Proceedings<\/strong>, Dallas, Texas, v. 16, n. 4, p. 379-383, 2003. DOI: https:\/\/doi.org\/10.1080\/08998280.2003.11927931.<\/p>

THE ASSOCIATION FOR MOLECULAR PATHOLOGY TRAINING AND EDUCATION COMMITTEE. Goals and objectives for molecular pathology education in residency programs.
The Journal of Molecular Diagnostics<\/strong>, v.1, n.1, p. 5-15, Nov. 1999. DOI: https:\/\/doi.org\/10.1016\/S1525-1578(10)60603-4.<\/p>

WECK, Karen E. The Next Generation of Molecular Pathology is Here: Validation of Next-Generation Sequencing Technology for Clinical Molecular Testing Across Multiple Different Disciplines. Archives of Pathology & Laboratory Medicine<\/strong>, v. 141, n. 6, p. 749-750, Jun. 2017. DOI: https:\/\/doi.org\/10.5858\/arpa.2017-0042-ED. <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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CONFIRA OS PRINCIPAIS TESTE REALIZADOS:<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel colorretal (KRAS + NRAS + BRAF)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMicrosatellite instability (MSI)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel GIST (KIT + PDGFRA + BRAF)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tIDH1 + IDH2<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMGMT<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel melanoma (BRAF + NRAS + KIT)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel pulm\u00e3o (EGFR + KRAS + BRAF + ERBB2)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tEGFR - \u00c9xons 18, 19, 20 e 21<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel multic\u00e2ncer (AKT1\/ BRAF\/ EGFR\/ ERBB2\/ FOXL2\/ GNA11\/ GNAQ\/ KIT\/ KRAS\/ MET\/ NRAS\/ PDGFRA\/ PIK3CA\/ RET\/ TP53)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPesquisa de amplifica\u00e7\u00e3o do HER2<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPesquisa de amplifica\u00e7\u00e3o do EGFR<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPesquisa de co-dele\u00e7\u00e3o do 1p19q<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPesquisa de amplifica\u00e7\u00e3o do MDM2<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene ALK<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene ROS1<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene SS18<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene FOXO1<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene FUS<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene PAX3\/FKHR<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene PAX7\/FKHR<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene BCL2<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene MYC<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene BCL6<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTransloca\u00e7\u00e3o envolvendo o gene NTRK1\/NTRK2\/NTRK3<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPainel c\u00e2ncer heridit\u00e1rio completo (ATM, APC, BARD1, BMPR1A,BRCA1, BRCA2, BRIP1, CDH1,CHEK2, EPCAM, FAM175A, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2,POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53, XRCC2).<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Patologia Molecular\/ Biologia Molecular Conhe\u00e7a o Exame Os exames de Patologia Molecular\/ Biologia Molecular consistem na avalia\u00e7\u00e3o minuciosa de altera\u00e7\u00f5es g\u00eanicas presentes em diversas cadeias de funcionamento do corpo humano. Dessa forma, podemos pesquisar desde uma altera\u00e7\u00e3o de uma \u00fanica cadeia de base do DNA, at\u00e9 quimerismos complexos de todo o cari\u00f3tipo ou exoma humano. […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"yoast_head":"\nPatologia Molecular\/ Biologia Molecular - Laborat\u00f3rio Di Prever<\/title>\n<meta name=\"description\" content=\"Fa\u00e7a seus exames Patologia Molecular\/ Biologia Molecular no Laborat\u00f3rio Di Prever. 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